| BMP2mRNA在骨折愈合过程中的表达及意义 |
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| 引用本文： | 司晓辉,杨连甲,金岩.BMP2mRNA在骨折愈合过程中的表达及意义[J].第四军医大学学报,1996(5). |
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| 作者姓名： | 司晓辉 杨连甲 金岩 |
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| 作者单位： | 第四军医大学口腔医学院病理科 |
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| 摘 要： | 目的：探讨骨形成蛋白（ＢＭＰ）在骨诱导过程中的作用机理．方法：建立骨折愈合模型，利用原位杂交方法检测骨折愈合过程中ＢＭＰ２ｍＲＮＡ的表达．结果：骨折后第５日间充质细胞、成骨细胞内均见阳性信号，第７日开始信号明显增强，软骨细胞内也可见阳性信号，第１４日后信号逐渐减弱．结论：在成骨活动活跃时，间充质细胞、成骨细胞、软骨细胞均有ＢＭＰ２ｍＲＮＡ的转录，然后编码形成ＢＭＰ２蛋白来促进及调节骨折的修复．
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| 关 键 词： | 骨形成蛋白 骨折愈合 原位杂交 |
Expression and significance of mRNA for BMP2 during fracture healing |
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| Si Xiaohui,Yang Lianjia,Jin Yan.Expression and significance of mRNA for BMP2 during fracture healing[J].Journal of the Fourth Military Medical University,1996(5). |
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| Authors: | Si Xiaohui Yang Lianjia Jin Yan |
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| Institution: | Si Xiaohui,Yang Lianjia,Jin Yan Department of Oral Pathology,Stomatological College,Fourth Military Medical University,Xi'an 710033 |
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| Abstract: | Objective: To elucidate the action of bone morphogenetic protein (BMP) during bone induction. Methods: An experimental model of fracture healing was used to detect BMP2 mRNA by non radioactive ISH. Results: By the 5th day after the fracture, mesenchymal cells and some osteoblasts showed BMP2 positive signals. By day 7, BMP2 mRNA expression was intense, chondrocytes also showed BMP2 positive signals. By day 14, reduced BMP2 mRNA expression was observed. Conclusion: These findings suggest that mesenchymal cells, chondrocytes and ostoblasts may transcribe BMP mRNA, synthesize BMP during active bone formation. |
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| Keywords: | bone morphogenetic protein fracture healing in situ hybridization |
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