Synthesis and biological activity of picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) analogues as potential antipsychotic agents |
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| Authors: | Gradillas Ana López Berta Braña Miguel F Sancho Isabel Pérez-García Carmen Alguacil Luis F |
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| Institution: | Departamento de Químicas, Facultad de Farmacia, Universidad San Pablo CEU, Boadilla del Monte, Madrid Spain. |
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| Abstract: | A series of analogues related to picobenzide (CAS 51832-87-2) have been prepared and have been used as starting material to obtain new trisubstituted oxazole derivatives. Two compounds showed a promising pharmacological profile in screening tests of antipsychotic activity, since they affected apomorphine-induced hyperactivity without significant effects on stereotypies. |
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