Wortmannilactones A-D, 22-membered triene macrolides from Talaromyces wortmannii |
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| Authors: | Dong Yuesheng Yang Junshan Zhang Hua Lin Jie Ren Xiao Liu Mei Lu Xinhua He Jiangong |
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| Affiliation: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, People's Republic of China. |
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| Abstract: | ![]()
The fungus Talaromyces wortmannii, isolated from a soil sample collected in China's Yunnan province, produced four novel 22-membered macrolides, namely, wortmannilactones A-D (1-4). Structures 1-4 were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Compounds 1-4 exhibited in vitro cytotoxic activity against several human cancer cell lines with IC50 values ranging from 28.7 to 130.5 microM. |
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