肌酸在肌少-骨质疏松症中的应用与研究进展

肌少-骨质疏松症是肌少症与骨质疏松症并存的一种老年综合征。肌少-骨质疏松症因社会老龄化进程不断加深成为老年人健康的巨大威胁。目前强有力的证据指出特定饮食干预措施对防治肌少-骨质疏松症有着有益的功效,其中蛋白质、氨基酸和肌酸是这方面研究较多的营养素,与蛋白质、氨基酸相比,对肌酸的研究相对较少。因此,该综述旨在总结最近关于肌酸补充作为辅助治疗在防治肌少-骨质疏松症方面的应用研究结果,初步阐述肌酸在骨、肌肉和脂肪的作用。该文为研究肌酸对骨、肌肉和脂肪的作用机理提供新的研究思路,同时也为防治肌少-骨质疏松症提供新的临床思路。尽管目前服用肌酸对骨、肌肉作用观点不一,但充分证据表明补充适量的肌酸有助于防治肌少-骨质疏松症。

Application and research progress of creatine in sarco-osteoporosis

Sarco-osteoporosis is a geriatric syndrome in which sarcopenia coexists with osteoporosis. Sarco-osteoporosis has become a significant health threat to the elderly due to the increasing aging process of the society. There is currently strong evidence pointing to the beneficial effects of specific dietary interventions to prevent sarco-osteoporosis. Protein, amino acids, and creatine being the most studied nutrients in this regard. However, creatine has been much less studied than others. Therefore, this review aims to summarize the results of recent studies on the use of creatine supplementation as adjuvent therapy in the prevention of sarco-osteoporosis. The preliminary elaboration of the role of creatine in bone, muscle, and fat may provide new research ideas not only for the study of the possible mechanism of creatine on bone, muscle, and fat, but also for the prevention and treatment sarco-osteoporosis. Although there are conflicting views in the effects of creatine administration on bone, muscle, and fat, there is ample evidence that supplementation with appropriate amounts of creatine may help to reduce sarco-osteoporosis.