| 红内期疟原虫生长规律的一个数学模型 |
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| 引用本文： | 胡志光,方积乾,程道新.红内期疟原虫生长规律的一个数学模型[J].北京大学学报(医学版),1991(5). |
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| 作者姓名： | 胡志光 方积乾 程道新 |
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| 作者单位： | 北京医科大学生物教学与生物统计学教研室
(胡志光，方积乾)，北京医科大学寄生虫学教研室(程道新) |
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| 摘 要： | 由于引起疟疾临床症状的主要时期是红内期疟原虫,其发育规律的研究有助于疟疾的治疗。本文着重研究的是疟原虫进入红细胞进行裂体增殖的全过程。采用数学模型的方法研究红内期变化规律,不仅定量地描述了红内期各阶段的转化过程,而且为进一步探索红内期发育过程与免疫、吞噬、营养等因素的联系奠定了基础。
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| 关 键 词： | 红内期 转移概率 数学模型 |
A MATHEMATICAL MODEL FOR GROWTH PATTERN OF PLASMODIUM IN ERYTHROCYTE STAGE |
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| Hu Zhiguang.A MATHEMATICAL MODEL FOR GROWTH PATTERN OF PLASMODIUM IN ERYTHROCYTE STAGE[J].Journal of Peking University:Health Sciences,1991(5). |
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| Authors: | Hu Zhiguang |
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| Institution: | Hu Zhiguang Department of Biomathematics and Biostatistics |
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| Abstract: | The growth pattern of plasmodium in erythrocyte stage is modelled with a finite-stage Markovprocess, which describes quantitatively the laws of transitions and death of infected red cells invarious states during erythrocyte stage. As new methodology, it facilitates further studies on lifecycle of plasmodium and the effects of relevant internal and external factors. The derivative-freeprocedure of optimization is used in parameter estimation with the criterion of least square. Theanalysis of a set of animal experimental data shows the model fits well and gives some results whichhave not been issued with other methods. |
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| Keywords: | Erythrocyte stage Transition probability Mathematical modal |
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