Th17细胞及其在慢性阻塞性肺疾病中的作用

最近研究发现一类不同于Th1和Th2的CD4+T细胞亚群-Th17细胞亚群.白介素6(IL-6)及转化生长因子β(TGF-β)是促进Th17分化的关键细胞因子.转录调节因子孤核受体是特异性调节Th17分化及功能的转录调节因子.目前慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的发病机制未明,慢性气道炎症特别是中性粒细胞的募集和激活被认为在COPD的发病中占有重要作用.Th17细胞通过其主要效应因子IL-17刺激IL-6、IL-8、粒巨噬细胞集落刺激因子及巨噬细胞炎性蛋白2等前炎症细胞因子招募中性粒细胞,同时促使气道黏液高分泌,调节气道重构,最终作用到相应的靶器官.随着Th17细胞研究的深入,有助于进一步阐明COPD的发病机制.

Th17 cells and its role in chronic obstructive pulmonary disease

Recently a third group of cells termed Th17 has been identified.These cells follow a distinct differentiation profile requiring TGF-βand IL-6 leading to the expression of the Th17 selective transcription factor,RORγt.The pathogenesis of chronic obstructive pulmonary disease(COPD)is not entirely known.Chronic inflammation is a key feature of many airway diseases.Leukocyte accumulation in the lung has the capacity to mediate many aspects of the path physiology of COPD.IL-17 is the main effect factor of Th17 cells.It can stimulate pro-inflammatory cytokines such as IL-6,IL-8,GM-CSF and MIP-2 to recruit neutrophils.At the same time,airway mucus hypersecretion and regulation of airway remodeling also attribute to IL-17.With the research on Th17 cell,we can know more about the pathogenesis of COPD.