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Experimental Infection of Peromyscus Species Rodents with Sin Nombre Virus |
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| Authors: | Kaye Quizon Kimberly Holloway Mahmood Iranpour Bryce M. Warner Yvon Deschambault Geoff Soule Kevin Tierney Darwyn Kobasa Angela Sloan David Safronetz |
| Affiliation: | Public Health Agency of Canada, Winnipeg, Manitoba, Canada (K. Quizon, K. Holloway, M. Iranpour, B.M. Warner, Y. Deschambault, G. Soule, K. Tierney, D. Kobasa, A. Sloan, D. Safronetz);University of Manitoba, Winnipeg (D. Kobasa, D. Safronetz) |
| Abstract: | We demonstrate that 6 distinct Peromyscus rodent species are permissive to experimental infection with Sin Nombre orthohantavirus (SNV). Viral RNA and SNV antibodies were detected in members of all 6 species. P. leucopus mice demonstrated markedly higher viral and antibody titers than P. maniculatus mice, the established primary hosts for SNV. |
| Keywords: | Sin Nombre virus viruses Peromyscus Peromyscus leucopus Peromyscus maniculatus rodents Orthohantaviruses hantavirus cardiopulmonary syndrome |