胎儿生长受限与正常妊娠孕妇血清皮质醇浓度、APOAI/APOB变化的研究

目的:探讨正常妊娠和胎儿生长受限孕妇血清皮质醇浓度和ApoAI/ApoB的变化,以及这些改变与胎儿生长受限发病的关系。方法:采用放射免疫法及免疫透射比浊法,测定50例胎儿生长受限孕妇、294例正常妊娠孕妇、56例非妊娠妇女(对照组)的血清皮质醇浓度、载脂蛋白ApoAI、AgpoB和ApoAI/ApoB比值。结果:正常妊娠孕妇血清皮质醇浓度、ApoAI和ApoB含量随着孕周增长而升高,较对照组有显著差异性(P<0.01),ApoAI/ApoB比值随着孕周增长略有上升(P>0.05)。与正常妊娠组比较,胎儿生长受限组皮质醇浓度显著升高(P<0.01),ApoAI/ApoB明显下降(P<0.01)。结论:测定孕妇血清皮质醇浓度、ApoAI/ApoB比值可作为孕期早期诊断胎儿生长受限的指标。

Study of relationship between serum cortisol concentration and the change of ApoAI/ApoB in pregnant women with fetal grown restriction and normotensive pregnant women

Objective:To investigate the serum cortisol concentration and the change of ApoAI / ApoB in pregnant women with fetal grown restriction(FGR),normotensive pregnant women and non-pregnant women.Methods:50 women with FGR,294 normotensive pregnant women and 56 non-pregnant ones were studied,from whom maternal blood samples were collected.The serum cortisol concentration were determined by radioimmunoassay(RIA) and ApoAI and ApoB levels by radial immunodiffusion.Results:Following pregnancy progress,the serum cortisol concentration and the levels of ApoAI and ApoB were higher in normotensive pregnant women than those in non-pregnant ones(P<0.01),and the change of ApoAI/ApoB tended to ascend(P>0.05).The serum cortisol concentration were higher in pregnant women with FGR than that in normotensive pregnant ones(P<0.01),the change of ApoAI/ApoB tended to descend(P<0.01).Conclusion:The serum cortisol concentration and the change of ApoAI/ApoB may be potential markers for FGR diagnosis.