妊娠期肝内胆汁淤积症围产儿185例结局分析

目的 探讨妊娠期肝内胆汁淤积症(ICP)对围产儿结局的影响.方法 回顾性选择2007年1月～2010年12月在本院住院分娩的ICP孕妇185例,其中轻度ICP 101例,重度ICP 84例,并选取同期100例正常妊娠者为对照组,比较两组间胎儿窘迫、羊水粪染、新生儿窒息、早产发生率、围产儿死亡率以及低体重等指标的差异.结果 ICP组各项指标明显高于对照组,差异有统计学意义(P<0.05),且重度ICP患者组的各项指标明显高于轻度组ICP患者,差异有统计学意义(P<0.05).结论 妊娠ICP对围产儿危害极大,且随病情的严重而增大,对ICP患者应做到早诊断,早治疗,严密孕期监护,从而降低围产儿患病率及死亡率,提高围产儿生存率.

Analysis of Perinatal Outcomes on 185 Pregnancy Women With Intrahepatic Cholestasis

ObjectiveTo explore the influence of intrahepatic cholestasis of pregnancy on perinatal outcomes.Methods185 pregnant women with ICP were as the study group,including 101 cases of mild patients and 84 cases of severe patients.At the same time 100 cases of normal pregnancy were chosen as the control group.A retrospective analysis was performed to compare the indexes including fetal distress,meconium staining,neonatal asphyxia,incidence of preterm birth,perinatal infant mortality and low birthweight among the groups.ResultsThe 6 indexes in ICP group were higher than in the control group,and there was statistical significance (P<0.05).The severe ICP group was significantly higher than the mild ICP group in the 6 indexes,and the difference was statistically significant (P<0.05).ConclusionPregnancy ICP is harmer to the perinatal,and it is increased with severity.For the patients with ICP,it is important to achieve early diagnosis and therapy,and strict pregnancy care for reducing the perinatal morbidity and improving perinatal survival rate.