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| 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的制备 | |
| 引用本文： | 戴桂元,刘德龙,刘蕴,王苏惠,王香善. 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的制备[J]. 中国医药工业杂志, 2004, 35(5): 261-262 |
| 作者姓名： | 戴桂元 刘德龙 刘蕴 王苏惠 王香善 |
| 作者单位： | 徐州师范大学化学系,江苏,徐州,221116 |
| 摘 要： | 以2,3,5-三甲基吡啶经N-氧化、硝化、甲氧基取代、乙酰化、水解、卤代及成盐等反应制得奥美拉唑中间体2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐,总收率63.6%.原料易得,反应条件温和,操作简便. |
| 关 键 词： | 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐 奥美拉唑 抗溃疡 中间体 合成 |
| 文章编号： | 1001-8255(2004)05-0261-02 |
Synthesis of 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine Hydrochloride |
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| DAI Gui-Yuan,LIU De-Long,LIU Yun,WANG Su-Hui,WANG Xiang-Shan. Synthesis of 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine Hydrochloride[J]. , 2004, 35(5): 261-262 | |
| Authors: | DAI Gui-Yuan LIU De-Long LIU Yun WANG Su-Hui WANG Xiang-Shan |
| Abstract: | The title compound was synthesized from 2,3,5-trimethylpyridine by N-oxidation, nitration, methoxylation,acylation and hydrolysis to give 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine which was chlorinated by SOCl2 andfollowed by salification in an overall yield of 63.6%. |
| Keywords: | chloromethyl-4-methoxy-3 5-dimethylpyridine hydrochloride omeprazole antiulcer intermediate synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |