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Clinical significance and prognostic value of apoptosis related proteins in superficial esophageal squamous cell carcinoma
Authors:Matsumoto M  Natsugoe S  Nakashima S  Okumura H  Sakita H  Baba M  Takao S  Aikou T
Affiliation:(1) First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan;(2) First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Abstract:Background: The purpose of the present study was to examine the expression of cell cycle regulators [p53, p21WAF1/CIP1 (p21), and Rb] and apoptosis related proteins Bax and Bcl-XL and to evaluate the relationship between their expressions and clinicopathological findings in patients with superficial squamous cell carcinomas of the esophagus.Methods: We immunohistochemically investigated the expression of p53, p21, Rb, Bax, and Bcl-XL in 79 patients with superficial esophageal carcinoma.Results: p21 overexpression was found in mucosal carcinoma (P = 0.05) and a high Bcl-XL score was observed for submucosal carcinoma (P = 0.03). The patients with high Bcl-XL score had more frequent lymphatic invasion and lymph node metastasis than did those with low Bcl-XL score (P < 0.05). Univariate analysis revealed significantly shorter survival in patients with high Bcl-XL expression than in those with low Bcl-XL expression, but Bcl-XL expression was not identified as an independent prognostic factor by multivariate analysis.Conclusions: Because Bcl-Xl expression correlated well with depth of tumor invasion, lymphatic invasion, and lymph node metastasis, examination of Bcl-XL expression will help to estimate the properties in superficial squamous cell carcinoma of the esophagus.
Keywords:Superficial esophageal squamous cell carcinoma  p53 - p21WAF1/CIP1  Rb  Bax  Bcl-XL  Apoptosis
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