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| Synthesis of a new hydroxyethylene dipeptide isostere Phe ψ[CH2CH(OH)]Phe as HIV-1 protease inhibitor | |
| 作者姓名： | Huai Gu CHEN Tomi K SAWYER Peter G M WUTS (Upjohn Laboratories Process Research and Development The Upjohn Company Kalamazoo MI 49001 USA) Parke-Davis Pharmaceutical Research Division Warner-Lambert Co.2800 Plymouth Road Ann Arbor MI 48105 USA. |
| 作者单位： | Upjohn Laboratories，Process Research and Development，The Upjohn Company，Kalamazoo MI 49001，USA |
| 摘 要： | A new type of pseudodipeptide isostere exampled by Phe ψ[CH2CH(OH)]Phe was synthesized from phenylalanine. The H]V protease inhibitory activity (IC50) of Noa-His-Pheψ[CH2CH(OH)]Phe-Ile-Amp was 0. 8 pmol·L-1. |
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