| 家兔静脉灌注水杨酸钠对内毒素性发热及其脑中隔区精氨酸加压素含量的影响 |
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| 引用本文： | 王达安,董军,杨皓庄,李楚杰.家兔静脉灌注水杨酸钠对内毒素性发热及其脑中隔区精氨酸加压素含量的影响[J].中国病理生理杂志,1997(3). |
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| 作者姓名： | 王达安 董军 杨皓庄 李楚杰 |
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| 作者单位： | 暨南大学医学院病理生理学教研室，暨南大学医学院病理生理学教研室，暨南大学医学院病理生理学教研室，暨南大学医学院病理生理学教研室 广州 510632，广州 510632，广州 510632，广州 510632 |
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| 摘 要： | 本研究探讨了精氨酸加压素在水杨酸解热机制中的作用。实验结果表明:在静脉注射内毒素引起发热时,脑中隔区的精氨酸加压素含量明显升高(P<0.01);而静脉注射水杨酸钠1.3mol/L×2ml随后以24mmol/L×2ml/min恒速灌注,在抑制发热的同时,也消除了精氨酸加压素含量的升高(P<0.01)。作者推论:脑中隔区精氨酸加压素释放的增加可能参与水杨酸的解热过程。
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| 关 键 词： | 内毒素 发热 水杨酸盐类 精氨酸加压素 |
The effects of sodium salicylate on febrile response and arginine vasopressin contents in the ventral septum after intravenous injection of endotoxin into rabbits |
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| Wang Da-An,Dong Jun,Yang Hao-Zhuang,Li Chu-Jie.The effects of sodium salicylate on febrile response and arginine vasopressin contents in the ventral septum after intravenous injection of endotoxin into rabbits[J].Chinese Journal of Pathophysiology,1997(3). |
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| Authors: | Wang Da-An Dong Jun Yang Hao-Zhuang Li Chu-Jie |
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| Abstract: | The experiment was designed to study the role of arginine vasopressin in salicylate -induced antipyresis. The results indicated that body temperature as well as arginine vasopressin contents in the septum increased significantly after intravenous injec-(1011 of endotoxin(P<0.01), and the effects could be prevented by intravenous infusion of sodium salicylate(24mmol/LX2ml/min,following an initial dose of 1.3mol/L X 2ml)(P<0.01). The authors proposed that the increase in arginine vasopressin release in the septum may participate in salicylate -induced antipyresis. |
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