Cdc25A 与非小细胞肺癌

肺癌是目前全世界范围内发病率及病死率最高的恶性肿瘤，其中非小细胞肺癌占肺癌总数80%以上。Cdc25A 是 Cdc25磷酸酶3种同源物之一，是一种双特异性蛋白激酶，也是最重要的细胞周期调节因子和凋亡因子。研究发现 Cdc25A 在多种肿瘤中表达上调，发挥癌基因作用。Cdc25A被认为是细胞发育和肿瘤形成、进展和转移中必不可少的调控因子，但其在非小细胞肺癌发生中的确切作用机制和临床意义仍不十分明确。

Cdc25A and non-small cell lung cancer

Lung cancer is the malignant tumor with the highest morbidity and mortality worldwide and 80% of lung cancer is non-small cell lung cancer.Cdc25A,one of the three isoforms of Cdc25 phosphatase,is a dual specificity phosphatase,and also is the most important cell cycle regulation factor and apoptosis factor.Studies have showed that the expression of Cdc25A which acts as oncogene upregulates in many tumors.Cdc25A is considered as an essential control factor in cell growth and tumor formation,progression and metastasis,but its specific mechanism in non-small cell lung cancer is still not very clear.