| 抗体介导的排斥反应与临床 |
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| 引用本文： | 蔡俊超. 抗体介导的排斥反应与临床[J]. 中华移植杂志(电子版), 2010, 0(4) |
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| 作者姓名： | 蔡俊超 |
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| 作者单位： | Terasaki Foundation Laboratory; |
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| 摘 要： | 随着器官移植体液免疫理论的发展与抗体检测技术的进步,抗体介导的排斥反应(AMR)已逐渐被认识和引起关注。其治疗难度大、逆转率较低,已成为导致移植物失功的重要原因。本文较为系统地介绍了AMR的免疫机制、诊断与防治进展,以及供者特异性抗体的检测技术和临床意义,从而提出供者特异性抗体是引起移植物排斥反应特别是慢性排斥反应的主要原因,移植受者需常规监测抗体以利及时干预和治疗。
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| 关 键 词： | 器官移植 抗体 供者特异性抗体 抗体介导的排斥反应 Banff标准 |
Antibody mediated rejection |
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| CAI Jun-chao.Terasaki Foundation Laboratory,Los Angeles,CA ,USA. Antibody mediated rejection[J]. Chinese Journal of Transplanation(Electronic Version), 2010, 0(4) |
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| Authors: | CAI Jun-chao.Terasaki Foundation Laboratory Los Angeles CA USA |
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| Affiliation: | CAI Jun-chao.Terasaki Foundation Laboratory,Los Angeles,CA 90064,USA |
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| Abstract: | As the development of humoral immune theory and the technique of antibody detection,antibody-mediated rejection(AMR) has been increasingly recognized.As the treatment of AMR is difficult and the reverse rate is relatively low,AMR has become a major cause of graft dysfunction.This article systemicallyintroduced the immune mechanism,diagnosis and treatment of AMR,and the detection of donor-specificantibodies and their clinical significance.We suggested that the donor-specific antibodies were the main cause fo... |
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| Keywords: | Organ transplantation Antibodies Donor-specific antibodies Antibody mediated rejection Banff criteria |
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