Appointment Nonadherence and Graft Outcomes in Living Donor Kidney Transplantation |
| |
| Affiliation: | 1. Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan;2. Department of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan;3. Department of Urology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan;1. Department of Transplantation and Regenerative Medicine, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan;2. Department of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan;3. Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan;1. Department of Surgery, University of Illinois at Chicago, Illinois;2. Department of Pathology, University of Illinois at Chicago, Illinois;3. Department of Pharmacy Practice, University of Illinois at Chicago, Illinois;1. Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan;2. Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan;3. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan;4. Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan;5. Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan;6. Division of Nephrology, Department of Internal Medicine, Taichung VeteransTaichung, Taiwan;7. Department of Post-Baccalaureate Medicine, College of Medicine, NationalTaichung, Taiwan;8. Department of Life Science, Tunghai University, Taichung, Taiwan;9. School of Medicine, China Medical University, Taichung, Taiwan;1. Department of Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea;1. Department of Urology, Tokyo Women''s Medical University, Tokyo, Japan;2. Department of Nephrology, Tokyo Women''s Medical University, Tokyo, Japan;3. Department of Organ Transplant Medicine, Tokyo Women''s Medical University, Tokyo, Japan |
| |
| Abstract: | BackgroundMedication nonadherence is associated with worse graft outcomes but is hard to recognize in clinical settings due to its self-reporting nature. We hypothesized that appointment nonadherence might be associated with worse graft outcomes in living donor kidney transplantation.MethodsWe included 167 adult living-donor kidney transplants whose grafts survived >2 years from April 2011 to May 2020. Thirty-two cases of appointment nonadherence were identified and compared with the controls (n = 135).ResultsYounger age, male sex, higher body weight, and parent donor were significantly observed in the appointment nonadherence group. The appointment nonadherence group was significantly associated with worse graft survival (5 years: 82.3% vs 98.9%, P < .001, 10 years: 67.2% vs 89.6%, P < .001), de novo donor-specific antibody production, acute rejection, as well as the decline of graft function. Furthermore, appointment nonadherence had a 4-fold higher risk of graft loss after an adjustment with recipient age, sex, body weight, and donor type (adjusted hazard ratio: 3.93, 95% CI: 1.15-13.42, P = .029).ConclusionsAppointment nonadherence might be an alternative predictor for worse graft outcomes after living donor kidney transplantation. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
