Murine models of posterolateral spinal fusion: A systematic review |
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| Affiliation: | 1. Department of Spine Surgery, P. Wertheimer University Hospital, GHE, hospices civils de Lyon, université Claude-Bernard Lyon 1, Lyon, France;2. Inserm UMR 1033, université Claude-Bernard Lyon 1, Lyon, France;3. Arts et métiers ParisTech, ENSAM, 151, boulevard de l’Hôpital, 75013 Paris, France;1. Department of Neurosurgery, Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain;2. Chief of department of Neurosurgery, Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain;1. Department of Neurosurgery, University Hospital of Caen, 14000 Caen, France;2. Normandie University, UNICAEN, Inserm, U1237, PhIND – Physiopathology and Imaging of Neurological Disorders, Institut Blood and Brain at Caen-Normandie, Cyceron, 14000 Caen, France;1. Neurosurgery department, Sainte-Anne Military Teaching Hospital, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France;2. École du Val-de-Grâce, French Military Health Service Academy, 1, place Alphonse-Laveran, 75230 Paris cedex 5, France;3. Val-de-Grâce Military Academy, 1, place Alphonse-Laveran, 75230 Paris cedex 5, France;1. Department of Neurosurgery, Duke University Medical Center, Duke Neurosurgery, 200 Trent Drive, Suite 1554, Durham NC, United States;2. Department of Anesthesiology, Duke University Medical Center, Duke Anesthesiology, DUHMC 3094, Durham 27710NC, United States;1. Department of Neurosurgery, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566 Kyoto, Japan;2. Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan;1. Department of Neurosurgery, Warren Alpert School of Medicine, Brown University, Providence, RI, 02903, United States;2. Department of Plastic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI, 02903, United States |
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| Abstract: | ![]()
BackgroundRodent models are commonly used experimentally to assess treatment effectiveness in spinal fusion. Certain factors are associated with better fusion rates. The objectives of the present study were to report the protocols most frequently used, to evaluate factors known to positively influence fusion rate, and to identify new factors.MethodA systematic literature search of PubMed and Web of Science found 139 experimental studies of posterolateral lumbar spinal fusion in rodent models. Data for level and location of fusion, animal strain, sex, weight and age, graft, decortication, fusion assessment and fusion and mortality rates were collected and analyzed.ResultsThe standard murine model for spinal fusion was male Sprague Dawley rats of 295 g weight and 13 weeks’ age, using decortication, with L4-L5 as fusion level. The last two criteria were associated with significantly better fusion rates. On manual palpation, the overall mean fusion rate in rats was 58% and the autograft mean fusion rate was 61%. Most studies evaluated fusion as a binary on manual palpation, and only a few used CT and histology. Average mortality was 3.03% in rats and 1.56% in mice.ConclusionsThese results suggest using a rat model, younger than 10 weeks and weighing more than 300 grams on the day of surgery, to optimize fusion rates, with decortication before grafting and fusing the L4-L5 level. |
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| Keywords: | Arthrodesis Rodent Decortication Fusion level Fusion assessment SD" },{" #name" :" keyword" ," $" :{" id" :" kw0035" }," $$" :[{" #name" :" text" ," _" :" standard deviation CT" },{" #name" :" keyword" ," $" :{" id" :" kw0045" }," $$" :[{" #name" :" text" ," _" :" computed tomography |
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