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急性坏死性胰腺炎时凝血功能的改变及其临床意义
引用本文:吴和光,严律南,张肇达,韦靖江,潘传芳,谭建三,陈玲琍,李昆能. 急性坏死性胰腺炎时凝血功能的改变及其临床意义[J]. 华西医学, 1990, 0(4)
作者姓名:吴和光  严律南  张肇达  韦靖江  潘传芳  谭建三  陈玲琍  李昆能
作者单位:华西医科大学外科教研室,华西医科大学外科教研室,华西医科大学外科教研室,华西医科大学外科教研室,华西医科大学内科血液实验室,华西医科大学公共卫生学院病理学教研室,华西医科大学外科实验室,华西医科大学外科实验室
摘    要:
作者通过28只犬观察了急性坏死性胰腺炎(ANP)时血液凝血象变化,发现在诱发犬的ANP后出现血小板、纤维蛋白原及凝血因子的消耗及纤溶激活。作者认为ANP时胰酶及毒性产物的大量入血,激活了凝血纤溶系统,是导致胰腺微循环中血栓形成的重要原因之一,在ANP病变恶化过程中占有一定地位。

关 键 词:急性坏死性胰腺炎  凝血功能  胰腺微循环

Coagulation Abnormalities in Experimental Acute Necrotizing Pancratitis
Yan Lunan,et al First University Hospital,West China University of Medical Sciences,Chengdu. Coagulation Abnormalities in Experimental Acute Necrotizing Pancratitis[J]. West China Medical Journal, 1990, 0(4)
Authors:Yan Lunan  et al First University Hospital  West China University of Medical Sciences  Chengdu
Abstract:
Alterations of coagulation functions in acute necrotizing pancreatitis(ANP) had been studied in 28 dogs. The results showed that after the induction of ANP, the consumption of platelets, fibrinogen and coagulation factors and the activation of fibrinolysis were observed. The authors suggest-ed that during the early stage of ANP, pancreatic enzymes and toxic products enter-ed the systemic circulation and contri-buted the activation of coagulation and fibrinolysis system, which was one of the causative factors of microcirculation thrombosis and may play a role on pathogenesis in ANP.
Keywords:Acute Necrotizing pancreatitis  Coagulation functions  Pancreatic microcirculation
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