| MRI对浸润性乳腺癌新辅助化疗疗效的评估价值 |
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| 引用本文： | 胡静,赵亚娥,汪登斌,沈坤炜,李亚芬,陈伟国,柴维敏,姜婷婷,王露岚,李志. MRI对浸润性乳腺癌新辅助化疗疗效的评估价值[J]. 外科理论与实践, 2011, 16(1): 29-34. DOI: 10.16139/j.1007-9610.a2622 |
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| 作者姓名： | 胡静 赵亚娥 汪登斌 沈坤炜 李亚芬 陈伟国 柴维敏 姜婷婷 王露岚 李志 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院放射科;上海市东医院放射科;上海交通大学医学院附属瑞金医院乳腺疾病诊治中心; |
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| 基金项目： | 上海市科委创新行动计划纳米专项研究项目(0852nm04600); 上海市教育委员会科研创新重点项目(09zz112) |
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| 摘 要： | 目的:探讨MRI在评价新辅助化疗治疗浸润性乳腺癌方面的价值。方法:回顾性分析20例行术前新辅助化疗,并行化疗前、后MRI检查的浸润性乳腺癌病人。将其病理学反应分为5级;4级和5级为组织学显著反应(majorhistological response,MHR),并以此作为参考标准,以图像表现作为对照。所有影像资料由两位医师通过诊断工作站共同阅片,判断是否属MHR;意见不一致时,咨询另一位资深医师。用Kappa分析对MRI判读结果与参考标准间进行一致性检验。结果:MRI对化疗后浸润癌残余的诊断与参考标准间的一致性较好,Kappa值为0.6。新辅助化疗后乳腺癌病灶明显缩小(P<0.05)。结论:MRI在乳腺癌新辅助化疗疗效的无创性评价方面具有较大价值。
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| 关 键 词： | 乳腺癌 新辅助化疗 磁共振成像 病理学反应性 治疗疗效 |
Evaluation of the therapeutic effects of neoadjuvant chemotherapy in invasive breast cancer using magnetic resonance imaging |
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| HU Jing,ZHAO Ya-e,WANG Deng-bin,SHEN Kun-wei,LI Ya-fen,CHEN Wei-guo,CHAI Wei-min,JIANG Ting-ting,WANG Lu-lan,LI Zhi. Evaluation of the therapeutic effects of neoadjuvant chemotherapy in invasive breast cancer using magnetic resonance imaging[J]. Journal of Surgery Concepts & Practice, 2011, 16(1): 29-34. DOI: 10.16139/j.1007-9610.a2622 |
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| Authors: | HU Jing ZHAO Ya-e WANG Deng-bin SHEN Kun-wei LI Ya-fen CHEN Wei-guo CHAI Wei-min JIANG Ting-ting WANG Lu-lan LI Zhi |
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| Affiliation: | HU Jing1a,ZHAO Ya-e2,WANG Deng-bin1a,SHEN Kun-wei1b,LI Ya-fen1b,CHEN Wei-guo1b,CHAI Wei-min1a,JIANG Ting-ting1a,WANG Lu-lan1a,LI Zhi1a.1a.Department of Radiology,1b.Comprehensive Breast Health Center,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China,2.Department of Radiology,Shanghai Shidong Hospital,Shanghai 200438 |
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| Abstract: | Objective To explore the value of magnetic resonance imaging(MRI) in evaluating the therapeutic effects of neoadjuvant chemotherapy in invasive breast cancer.Methods Twenty cases of invasive breast cancers with MRI examination both before and after neoadjuvant chemotherapy were retrospectively analyzed.The pathological response was divided into 5 grades: grade 4 and 5 were referred to as major histological response(MHR).The imaging features of the cases were compared with this notation.All the images were r... |
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| Keywords: | Breast cancer Neoadjuvant chemotherapy Magnetic resonance imaging Pathological response Therapeutic effects |
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