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| 高效液相色谱法测定依达拉奉的含量 | |
| 引用本文： | 苏勍,莫宗琪,孔凡贞. 高效液相色谱法测定依达拉奉的含量[J]. 实用医药杂志(山东), 2005, 22(9): 811-812 |
| 作者姓名： | 苏勍 莫宗琪 孔凡贞 |
| 作者单位： | 济南军区青岛第一疗养院药剂科 山东青岛266071(苏勍，莫宗琪)，济南军区青岛第一疗养院药剂科 山东青岛266071(孔凡贞) |
| 摘 要： | 目的建立依达拉奉含量的HPLC测定方法。方法采用KromasilC18色谱柱(250×4.6mm,5μm),以甲醇-0.05mol/L磷酸二氢铵溶液(50∶50;用磷酸调pH至3.0)为流动相,流速为0.8ml/min熏检测波长为245nm。结果依达拉奉在10～50μg/ml的浓度范围内呈良好的线性关系穴r=0.9997雪,平均回收率(n=9)为100.10%,RSD=1.3%。结论本方法简便快速,结果准确可靠,可以作为依达拉奉的含量测定方法。 |
| 关 键 词： | 依达拉奉 高效液相色谱法 含量测定 |
| 修稿时间： | 2005-05-16 |
HPLC determination of Edaravone |
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| SU Qing,MO Zongqi,KONG Fanzhen. Qingdao No. Sanatorium of Jinan Military. Region,Qingdao ,China. HPLC determination of Edaravone[J]. Practical Journal of Medicine & Pharmacy, 2005, 22(9): 811-812 | |
| Authors: | SU Qing MO Zongqi KONG Fanzhen. Qingdao No. Sanatorium of Jinan Military. Region Qingdao China |
| Affiliation: | SU Qing,MO Zongqi,KONG Fanzhen. Qingdao No.1 Sanatorium of Jinan Military. Region,Qingdao 266071,China |
| Abstract: | Objective To establish an HPLC method for the determination of edaravone.Method Kromasil C18 column was adopted, and methyl alcohol-0.05mol/L NH4H2PO4 solution(50:50,adjust to pH 3.0 with phosphoric acid) was taken as the mobile phase at the flow rate of 0.8mL/min.The detection wavelength was 245nm.Results Edaravone showed good linearity(r=0.9997)in the range of 10-50μg/mL.The average recovery rate (n=9)was 100.10%,RSD=1.3%.Conclusion The method is simple,accurate and can be used for determination of Edaravone. |
| Keywords: | Edaravone HPLC Quantitative determination |
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