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EGFR蛋白在喉鳞状细胞癌中的表达及临床意义
引用本文:阳光,杨长亮,姚行齐. EGFR蛋白在喉鳞状细胞癌中的表达及临床意义[J]. 华南国防医学杂志, 2014, 0(11): 1064-1066
作者姓名:阳光  杨长亮  姚行齐
作者单位:广州军区武汉总医院耳鼻咽喉头颈外科
摘    要:目的探讨表皮生长因子受体(epithelial growth factor receptor,EGFR)蛋白在喉鳞状细胞癌中表达的临床意义。方法应用免疫组织化学-链霉菌抗生物素蛋白-过氧化物酶连结法(streptavidin-perosidase,SP)检测58例喉鳞状细胞癌和15例正常喉黏膜标本中EGFR蛋白的表达。结果 EGFR蛋白在喉鳞状细胞癌和正常口腔黏膜标本的表达阳性率分别为72.41%和6.67%(P〈0.01)。EGFR蛋白与年龄、性别、浸润程度和淋巴结转移之间的差异无统计学意义(P〉0.05),但是与肿瘤分期、肿瘤分化程度的差异有统计学意义(P〈0.01)。结论 EGFR可能参与喉鳞状细胞癌发生、发展,并且与喉鳞状细胞癌的分化有关,但是与浸润及转移可能无关。

关 键 词:表皮生长因子受体  喉鳞状细胞癌  临床意义

Protein Expression of Epidermal Growth Factor Receptor in Squamous Cell Carcinoma of Larynx
YANG Guano,YANG Chang-liang,YAO Hang-qi. Protein Expression of Epidermal Growth Factor Receptor in Squamous Cell Carcinoma of Larynx[J]. Military Medical Journal of South China, 2014, 0(11): 1064-1066
Authors:YANG Guano  YANG Chang-liang  YAO Hang-qi
Affiliation:(Department of Otolaryngology ,Wuhan General Hospital of Guangzhou Command ,Wuhan Hubei,430070,China)
Abstract:Objective To study the clinical significance of protein expression of epidermal growth factor receptor(EGFR)in squamous cell carcinoma of larynx.Methods The protein expression of EGFR in58 cases with squamous cell carcinoma of larynx and 15 cases of normal human oral mucous membrane were detected using techniques of immunohistochemi stry streptavidin-perosidase(SP)method.Results The positive percentages of EGFR protein expression in squamous cell carcinoma of larynx and normal human laryngic mucous membrane were respectively 72.41% and 6.67%(P〈0.01).The positive percentage of EGFR protein expression in squamous cell carcinoma of head and neck were not related to gender,age,infiltration degree and metastasis(P〉0.05),but were related to neoplasm staging and differentiation degree(P〈0.01).Conclusion EGFR may be related to the tumorigenesis and tumor progression of squamous cell carcinoma of larynx,and may play key roles in differentiation,but may have no relation to infiltration and metastasis.
Keywords:Epidermal growth factor receptor  Squamous cell carcinoma of larynx  Clinical significance
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