| 可溶性白细胞介素2受体（sIL－2R）在慢性乙肝发病机理中的意义 |
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| 引用本文： | 吴广利,严玉兰,张树林,陈太平,赵英仁,李义方. 可溶性白细胞介素2受体（sIL－2R）在慢性乙肝发病机理中的意义[J]. 滨州医学院学报, 1994, 0(1) |
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| 作者姓名： | 吴广利 严玉兰 张树林 陈太平 赵英仁 李义方 |
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| 作者单位： | 西安医科大学第一临床医学院肝炎研究室 |
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| 摘 要： | 以双单克隆抗体夹心ＥＬＩＳＡ法检测８１例慢性乙肝患者（慢性迁延性肝炎１０例,慢性活动性肝炎３８例,肝炎后肝硬化１３例,慢性重症肝炎２０例）血浆与外周血单个核细胞培养上清液中的ｓＩＬ－２Ｒ。结果显示,不同临床类型的慢性乙肝血浆ｓＩＬ－２Ｒ水平均明显高子正常对照组（Ｐ均＜０．０１）。除慢活肝与肝炎后肝硬化的ｓＩＬ－２Ｒ水平未见明显差异外（Ｐ＞０．０５）,其余各组差异显著（Ｐ＜０．０１）。而不同临床类型的慢性乙肝之间及与正常对照组间外周血单个核细胞培养上清液中的ｓＩＬ－２Ｒ水平差异无显著性（Ｐ均＞０．０５）。提示不同临床类型的慢性乙肝都存在免疫效应细胞的过度活化,慢性乙肝患者的ＰＢＭＣ体外释放ｓＩＬ－２Ｒ的能力无异常。
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| 关 键 词： | 慢性乙型肝炎 可溶性白细胞介素2受体 发病机理 |
THE SIGNIFICANCE OF SOLUBLE INTERLEUKIN-2 RECEPTOR (sIL-2R)IN THE PATHOGENESIS OF CHRONIC HEPATITIS B |
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| Wu Guangli, et al. THE SIGNIFICANCE OF SOLUBLE INTERLEUKIN-2 RECEPTOR (sIL-2R)IN THE PATHOGENESIS OF CHRONIC HEPATITIS B[J]. Journal of Binzhou Medical College, 1994, 0(1) |
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| Authors: | Wu Guangli et al |
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| Abstract: | Plasma level of sIL-2R and the sIL-2R level in supernatant of activated PBMC were measured by an "sandwith" enzyme-linked immunosorbent assay(ELISA) with two monoclonal antibodies in 81 cases of chronic hepatitis B. The results showed that the level of plasma sIL-2R in patients with different clinical types of chronic hepatitis B was obviously higher than that of plasma sIL-2R in healthy controls(P<0.01). No differences were demonstrated among different clinical types of chronic hepatitis B, different clinical types of chronic hepatitis B and healthy controls in sIL-2R realease from activated PBMC in vitro. The results indicate that there are activated immune competent cells in different clinical types of chronic hepatitis B. The ability of PMBC from patients to release sIL-2R in vitro is not different from the PBMC from controls. |
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| Keywords: | soluble interleukin-2 receptor chronic hepatitis B pathogenesis |
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