HPA蛋白的表达与食管鳞癌血管生成、浸润、转移的关系

目的 探讨HPA蛋白在食管鳞癌中的表达及其与食管鳞癌血管生成、浸润、转移的关系.方法 应用免疫组化法(Immunohistochmeistry,IHC)检测70例食管鳞癌组织和23例切缘正常组织中HPA、CD34蛋白的表达.结果 癌组织中HPA蛋白的表达(65.7%)显著高于切缘正常组织(0.0%)(P＜0.05).有淋巴结转移的食管鳞癌组织中HPA蛋白的阳性表达率90.9%(30/33)高于无淋巴结转移组43.2%(16/37)(P＜0.05);有纤维膜浸润的食管鳞癌组织中HPA蛋白的阳性表达率92.9%(39/42)高于无纤维膜浸润组25.0%(7/28)(P＜0.05).HPA蛋白阳性表达的食管鳞癌组织中的微血管密度(Mean Miciovessel Density,MVD)值(44.85±12.74)显著高于HPA蛋白阴性者的MVD值(33.05±7.32)(P＜0.05).结论 HPA蛋白阳性表达与食管鳞癌的发生、血管生成、浸润深度、淋巴结转移有关.

The relationship between the expression of HPA protein and the angiogenesis, invasion, metastasis of e-sophageal squamous cell carcinoma

Objectives To explore the expression of HPA protein in human esophageal squamous cell carcinoma and the relationship with the angiogenesis,invasion and metastasis.Methods The expression of HPA and CD34 protein in 23 incised margin normal tissues and 70 esophageal squamous cell carcinoma specimens was detected by immunohistochemical stain(IHC).Results The positive expression rate of HPA protein in esopageal squamous cell carcinoma(65.7%) was significant higher than that in incised margin normal tissues(0.0%)(P<0.05).The positive expression rate of HPA protein was 90.9% and 43.3% in the group of positive and negative lymph node metastasis respectively,the positive expression rate of HPA protein was 92.9% and 25.0% in the group of fibromembranous infiltration and no fibromembranous infiltration respectively,There was a significant difference between the two groups(P<0.05).MVD with positive expression of HPA protein in esophageal squamous cell carcinoma was significantly higher than that with negative expression(P<0.05).Conclusion The high expression of HPA protein could be correlated with carcinogenesis progression,angiogenesis,invasion and metastasis of esophageal squamous cell carcinoma.