Evaluation of white matter structures in patients with tinnitus using diffusion tensor imaging |
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| Affiliation: | 1. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, United States;2. Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, United States;3. Department of Neurophysiology, Nankai University School of Medicine, Tianjin, China;4. Boston CIDAR Study Group, Department of Psychiatry, Harvard Medical School, Boston, MA, United States;5. Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, Department of Psychiatry, Harvard Medical School, Boston, MA, United States;6. Departments of Psychiatry and Medicine, Harvard Medical School, at Brigham and Women''s Hospital, Connors Center for Women''s Health and Gender Biology, Boston, MA, United States |
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| Abstract: | ![]()
Recent functional imaging studies have demonstrated that the sensation of tinnitus is associated with activity in cortical regions functionally linked to subserve the generation, perception and processing of the tinnitus stimulus. Previous functional imaging studies have focused primarily on the cortical centers. However, none of these examined the functional nature of associated white matter interconnecting these cortical centers. In this study, we investigate the integrity of white matter tracts interconnecting the auditory system to the parietal and frontal corticies in tinnitus patients using diffusion tensor imaging. Our preliminary results suggest the possible involvement of associated white matter structures in addition to processing cortical centers in tinnitus patients compared with healthy subjects. |
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