Simultaneous production of high specific activity 64Cu and 61Co with 11.4 MeV protons on enriched 64Ni nuclei |
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| Institution: | 1. Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;2. Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA;3. Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA;4. Department of Engineering Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;5. Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA |
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| Abstract: | The 64Cu and 61Co radionuclides were produced simultaneously by irradiation of enriched 64Ni on a low energy proton-only cyclotron. Nickel targets were prepared by electrodeposition of enriched 64Ni (>95%) on Au backing at thicknesses of 25–225 mg/cm2 with efficiencies >99%. Irradiations up to 30 μA for 8 h were performed with 11.4 MeV protons using a water-cooled target mounting. Radiochemical separation of 64Cu and 61Co from 64Ni was performed by chromatography of the chlorocomplexes in a single step using an anion exchange resin column with a yield >95%. Using this method, the Ni target material was recovered and re-plated for subsequent production runs with an overall efficiency >96%. The excitation function for the 64Ni(p,n)64Cu reaction was measured and compared with published values. Experimental thick target saturation yields of 159 mCi/μA for 64Cu and 715 μCi/μA for 61Co were achieved. Typical specific activities of 64Cu were found to be 18.8±3.3 Ci/μmol. |
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