Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats |
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| Authors: | Prabu K Ananda CT Kumarappan Christudas Sunil VK Kalaichelvan |
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| Affiliation: | 1.Department of Pharmacology, Annamalai University, Annamalai Nagar, Chidambaram-608 002, India;2.Department of Life sciences, School of Pharmacy & Health Sciences, International Medical University, Kuala Lumpur, Malaysia;3.Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai-600 034, India |
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| Abstract: | ![]()
ObjectiveTo investigate the effect of aqueous solution of Biophytum sensitivum leaf extract (BSEt) on normal and streptozotocin (STZ)-nicotinamide-induced diabetic rats.MethodsDiabetes was induced in adult male Wistar rats by the administration of STZ-nicotinamide (40, 110 mg/kg b.w., respectively) intraperitoneally. BSEt (200 mg/kg) was administered to diabetic rats for 28 days. The effect of extract on blood glucose, plasma insulin, total haemoglobin, glycosylated haemoglobin, liver glycogen and carbohydrate metabolism regulating enzymes of liver was studied in diabetic rats.ResultsBSEt significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total haemoglobin, plasma insulin and liver glycogen levels in diabetic rats. It also increased the hexokinase activity and decreased glucose-6-phosphatase, fructose-1, 6-bisphosphatase activities in diabetic rats.ConclusionsThe results of our study suggest that BSEt possesses a promising effect on STZ-nicotinamide-induced diabetes. |
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| Keywords: | Biophytum sensitivum Carbohydrate metabolism Diabetes mellitus Streptozotocin-nicotinamide |
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