BED捕获酶联免疫法检测广西某吸毒监测哨点HIV新近感染率

目的 了解广西某吸毒监测哨点注射吸毒人群(injection drug users,IDU)的HIV新近感染情况,估算HIV新近感染率.方法 对广西某吸毒监测哨点2005-2007年787份血清样本进行监测,以酶联免疫吸附试验(ELISA)筛检出168份HIV-1阳性样本,再经BED捕获酶联免疫法(BED capture enzyme immunoassay,BED-CEIA)检测出其中新近感染的样本共17份,获得该人群HIV-1的新近感染率.结果 787份监测样本中共筛检出HIV-1确认阳性样本168份,新近感染样本17份.该哨点2005-2007年HIV感染率分别为23.06%(92/399)、21.90%(46/210)、16.85%(30/178),新近感染率分别为7.41%、6.94%、3.12%.结论 在广西某吸毒监测哨点IDU中,2005-2007年HIV新近感染率绝对数值有所降低,已发现的HIV感染者可能部分为既往感染者.

Detection of HTV incidence using BED capture enzyme immunoassay at a surveillance sentinel site of injection drug users in Guangxi

Objective To detect recent HIV incidence of injection drug users ( IDU) from a surveillance site of IDU in Guangxi and estimate HIV incidence. Methods 787 Samples from a IDU surveillance sentinel site in Guangxi (2005-2007) were collected for ELISA and 168 were HIV-1 positive;then 168 HIV-1 positive samples were detected by BED capture enzyme immunoassay (BED-CEIA) and 17 were positive. Results A total. of 787 samples were tested and 168 were HIV-1 positive and 17 were BED- CEIA positive. The prevalence rates of the IDU surveillance sentinel site were 23. 06% (92/399) ,21. 90% (46/210) and 16. 85% (30/178 ) , and the incidence rates were 7. 41% ( 10/135) , 6. 94% (5/72) and 3. 12% (2/64) respectively from 2005 to 2007. Conclusion The incidence rate of HIV infections of IDU from a surveillance site of IDU in Guangxi appeared to decline slowly in recent years, and some might have been infected for long time.