氟脲脱氧核苷, 顺铂配合外照射治疗鼻咽癌的临床研究

 目的　观察比较氟脲脱氧核苷 ( FUDR)或氟脲嘧啶 ( 5 - FU)联合顺铂 ( DDP)配合外照射治疗鼻咽癌的近期疗效和急性毒副反应。方法 46例 期以上有颈部淋巴结转移病灶的鼻咽癌患者被随机分为 FUDR组和 5 - FU组。放疗前分别给予 FUDR1 0 0 0 mg/日 ,DDP2 0 mg/日或 5 -FU1 0 0 0 mg/日 ,DDP2 0 mg/日 ,静脉滴注 ,连续 5天。休息 3天后开始放疗 ,两组放疗剂量和方法相同。结果两组患者的总有效率 ( CR+ PR)分别为 96% ( FUDR组 )和 91 % ( 5 - FU组 ) ,无显著差异。重度口咽炎的发生率 FUDR组为 30 % ,5 - FU组为 65 % ( P<0 .0 5 ) .结论 FUDR加 DDP与 5 - FU加 DDP用于鼻咽癌诱导化疗相比较具有毒副作用小 ,患者易耐受的优点。

Preliminary Study on Patients with Nasopharyngeal Carcinoma Treated by Radiotherapy Combined with Fudr and Cisplatin

Objective To compare the response and side effects of FUDR plus DDP With 5|FU plus DDP fallowed by radiotherapy to treat patients with locally advanced nasopharyngeal carcinoma.Methods 46 patients with neck metastasis nasopharyngeal carcinoma were randomized into two groups:FUDR group or 5|FU group.FUDR 1000mg or 5|FU 1000mg plus DDP 20mg iv on day 1～5 for patients before radiotherapy.3 days after chemotherapy all patients received the same radiotherapy.Results 4 weeks after treatment,the effective rates...