硫酸氨基葡萄糖与膝关节腔内注射透明质酸铋联合治疗膝骨关节炎的效果观察

目的探讨膝骨关节炎患者采用硫酸氨基葡萄糖与膝关节腔内注射透明质酸钠联合治疗的临床效果。方法回顾性分析2010年9月-2013年4月在我院就诊的156例膝骨关节炎患者的临床资料，按照治疗方法不同分对照组和观察组（n=78），对照组患者采用硫酸氨基葡萄糖治疗，观察组在对照组的基础上采用膝关节腔内注射透明质酸钠治疗，比较两组患者的Womac关节炎指数、平均OA严重程度指数、VAS疼痛评分、膝骨关节炎X线分级及临床治疗总有效率。结果两组患者治疗后的Womac关节炎指数、平均OA严重程度指数及VAS疼痛评分与治疗前比较均出现明显的降低，治疗后观察组与对照组比较降低的幅度更大（P〈0．05）。观察组治疗后与治疗前比较1级患者所占比率明显升高，2级患者明显降低，治疗前后差异有统计学意义（P〈0．05）。观察组的总有效率与对照组比较明显较高，差异具有统计学意义（P〈0．05）。结论膝骨关节炎患者采用硫酸氨基葡萄糖与膝关节腔内注射透明质酸钠联合进行治疗能够收到较好的临床效果，可以在临床推广应用。

Effect of glucosamine sulfate combined intra-articular injection of sodium hyaluronate on knee osteoarthritis patients

Objective To investigate the clinical effect of knee osteoarthritis patients treated with glucosamine sulfate and intra-articular injection of sodium hyaluronate. Methods Retrospective analysis clinical data of 156 cases of patients with knee osteoarthritis who were collected from September 2010 to April 2013 in our hospital, according to the treatment they were divided into control group and observation group （n = 78）, the control group was treated with glucosamine sulfate, the observation group on the basis of the control group was given intra-articular injection of hyaluronic acid sodium, two groups of patients with Womac arthritis index, the average OA severity index, VAS pain scores, knee osteoarthritis X-ray grading and clinical treatment efficiency were compared. Results Womac arthritis index, the average OA severity index and the VAS pain score of two groups after treatment were significantly decreased than before treatment, observation group decreased significantly than the control group （P 〈 0.05）. The ratio of Grade 1 in the observation group after treatment increased than before treatment, Grade 2 patients ratio decreased significantly, with significant difference （P 〈 0.05）. Effective rate in the observation group was obviously higher than the control group, with significant difference （P 〈 0.05）. Conclusion Patients with knee osteoarthritis with glucosamine sulfate and intra-articular injection of sodium hyaluronate combined treatment can get good clinical effect, can be widely used in clinical practice.