厄贝沙坦联合硝苯地平缓释片治疗高血压30例疗效观察

目的 观察厄贝沙坦联合硝苯地平缓释片治疗高血压的临床效果.方法 采用随机数字表法将60例原发性高血压患者分成治疗组和对照组各30例,对照组应用硝苯地平缓释片10～20 mg口服治疗,每日2次；观察组在此基础上同时联合厄贝沙坦75 mg口服,每日1次.观察周期4周,比较两组的SBP、DBP治疗前后的变化情况以及不良反应情况.结果 治疗前,两组患者的SBP、DBP均未见明显差异,治疗4周后,两组患者的SBP、DBP分别较治疗前显著下降,且观察组比对照组血压降低水平更具有显著的差异性(P＜0.05).观察组有效率(93.3％)明显高于对照组(73.3％),两组有效率比较,差异具有统计学意义(P＜0.05).结论 厄贝沙坦联合硝苯地平缓释片治疗高血压降压效果较单独用药疗效好,是一种较为安全、有效的治疗方法,值得在临床上进一步推广运用.

Effect of irbesartan combined with nifedipine on 30 cases of hypertension

Objective To explore the clinical effect of irbesartan combined nifedipine treatment hypertension. Meth- ods All of 60 patients with essential hypertension were divided into treatment group and control group, each of 30 cas- es, the control group was given nifedipine sustained-release tablets 10-20 mg oral treatment, 2 times a day while ob- servation group on the basis of the control group was given irbesartan 75 mg orally once a day of 4 weeks,the SBP, DBP changes and adverse reactions were compared before and after treatment. Results Before treatment, the two groups of patients with SBP, DBP showed no significant difference, after 4 weeks of treatment, the two groups of patients with SBP, DBP respectively compared with before treatment decreased significantly, and the observation group decreased more significant than the control group, blood pressure decreased more significantly （P 〈 0.05）. The efficiency of the ob- servation group （93.3%） was significantly higher than the control group （73.3%）, there was a significant difference be tween two groups （P〈 0.05）. Conclusion Irbesartan treatment of hypertension antihypertensive effect of nifedipine than medication alone, and it is a safe, effective treatment, it is worth further promote the use of clinical efficacy.