2003年-2007年非发酵革兰阴性杆菌的耐药性变迁

目的调查分析2003-2007年临床分离的非发酵革兰阴性杆菌的分离和对抗菌药物耐药性变迁情况。方法采用VITEK-32全自动微生物分析仪和ATB自动微生物分析仪鉴定和药敏系统对临床分离的常见非发酵革兰氏阴性杆菌2880株进行鉴定和药敏试验。结果在五年观察中，我院3种常见的非发酵革兰氏阴性杆菌前3位依次是铜绿假单胞菌、鲍曼不动杆菌、嗜麦芽窄食单胞菌。5年中，除阿米卡星外，其余抗生素对2880株非发酵革兰氏阴性杆菌的耐药率均呈上升的趋势。尤其是铜绿假单胞菌对氨曲南、头孢旺肟、头孢哌酮／舒巴坦、亚胺培南，鲍曼不动杆菌对氨曲南耐药率上升明显，嗜麦芽窄食单胞菌对10种抗生素呈现多重耐药，除复方新诺明耐药率较低外，其余均在33.6％，100％。结论动态了解常见非发酵革兰氏阴性杆菌的分离率和对抗菌药物耐药性变迁情况，有助于临床合理选用抗生素，提高治愈率。

Drug resistance evolution of non-fermentative Gram-negative bacillus from 2003 to 2007

Objective To isolate non-fermentative Gram-negative bacillus and analyze its drug resistance evolution from 2003 to 2007. Methods The characterization and drug sensitivity test of 2880 clinical isolates of non-fermentative Gram-negative bacillus were done by VITEK-32 automatic microbe system and ATB microbial analysis system. Results The first three common non-fermentative Gram-negative bacillus were successively Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas maltophilia in our hospita...