基于中医证素辨证的糖尿病心脏自主神经病变研究

目的：基于中医证素辨证体系探讨糖尿病心脏自主神经病变的中医证型分布，为糖尿病心脏自主神经病变的辨证论治提供参考依据。方法：纳入101例糖尿病心脏自主神经病变患者，制定四诊信息采集表，建立数据库，采用因子分析、聚类分析等统计学方法及中医证素辨证方法，进行中医证候研究。结果：通过因子分析共获得16个公因子，进一步结合中医理论及临床知识进行聚类，依据证素辨证的方法共获得6个病性及3个病位证素，分别为气虚、血虚、阴虚、阳虚、热、血热与心、脾、肝。结论：对分析得出的病性及病位证素进行组合，获得4种有效中医证型，分别为阴虚热盛证、脾阳不振证、心气亏虚证及肝肾阴虚证。

Traditional Chinese Medicine Syndrome Types of Diabetic Cardiac Autonomic Neuropathy Based on Syndrome Element Differentiation

Objective:To explore the traditional Chinese medicine(TCM)syndrome types of diabetic cardiac autonomic neuropathy(DCAN)based on TCM syndrome factor differentiation,and to provide references for TCM syndrome differentiation of DCAN.Methods:One hundred and one patients with DCAN were included.A four-diagnostic-method information collection table for DCAN was formulated to establish a database.Statistical methods such as factor analysis and cluster analysis were applied as well as TCM syndrome element differentiation method,to conduct TCM syndrome research.Results:A total of 16 common factors were obtained by factor analysis,and a cluster analysis was performed in combination with TCM theory and clinical knowledge.Six elements of diseases properties and 3 elements of disease location were obtained.They were qi deficiency,blood deficiency,yin deficiency,yang deficiency,heat,blood heat,heart,spleen and liver.Conclusion:Four valid TCM syndrome types are obtained by combining the syndrome elements of disease property and disease location.They are syndrome of yin deficiency and heat excess,syndrome of spleen yang deficiency,syndrome of heart qi deficiency,and syndrome of liver and kidney yin deficiency.