CEA、CA153、CA199、CYFR21-1联合检测在乳腺癌诊断中的意义

目的：探讨乳腺癌患者血清癌胚抗原（CEA）、糖蛋白抗原（CA）153、CA199、细胞角蛋白片段（CYFR）21-1联合检测在乳腺癌诊断中的意义。方法选取经病理学诊断确诊为乳腺癌的60例患者作为乳腺癌组，选取30例良性乳腺病患者作为乳腺良性疾病组，40例体检结果正常的女性作为健康组。采用Beckman Coulter 快速微粒子酶免疫分析系统（IMX）检测患者血清CEA、CA153、CA199、CYFR21-1水平，分析CEA、CA153、CA199、CYFR21-1水平与乳腺癌临床特征之间的关系。结果乳腺癌组血清CEA、CA153、CA199、CYFR21-1水平均高于乳腺良性疾病组及健康组；乳腺癌组血清CEA、CA153、CA199、CYFR21-1联合检测的阳性率均高于单独检测的阳性率；4种指标联合检测对乳腺癌诊断的特异度及准确度无明显影响，灵敏度明显提高。结论血清CEA、CA153、CA199、CYFR21-1水平联合检测有助于乳腺癌的诊断。

Significance of combined detection of serum CEA,CA153 ,CA199 ,CYFR21-1 in breast cancer diagnosis

Objective To study the clinical significance of combined detection of serum CEA, CA153, CA199, CYFR21-1 in breast cancer diagnose. Methods We choose 60 breast cancer patients as the research objects,30 patients with benign breast disor ders and 40 healthy women as control. CEA,CA153 ,CA199 ,CYFR21-1 levels were detected by microparticle enzyme immunoassay （IMX） ,and the relationship between serum CEA,CA153,CA199,CYFR21-1 levels with breast cancer clinical features were ana- lyzed. Results CEA,CA153,CA199,CYFR21-1 levels in the serum of breast cancer patients were significantly higher than that in control group. The combined detection can improve the positive rate in the group of breast cancer. The combined detecting can in- crease the diagnosis sensitivity in the group of breast cancer,but the specificity and the accuracy keep the same. Conclusion Com- bined detection of serum CEA,CA153,CA199 ,CYFR21-1 have important value in the diagnosis of breast cancer.