经间期出血发病机制临床初探

目的探讨经间期出血患者的发病机制。方法将70例经间期出血患者(观察组)与35例月经正常者(正常组)进行对照,监测2组月经不同时期的子宫内膜厚度、内分泌指标和凝血指标。结果观察组在月经7～10d子宫内膜显著增厚,而21～25d显著变薄。在月经1～3d血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P0)水平显著升高;7～10dLH显著升高,E2显著下降;21～25dE2、P0均显著下降。凝血指标无明显变化。结论排卵前期低水平的雌激素不足以支持此期相对增厚的子宫内膜而出现少量的突破性出血,与凝血机制无明显关联。

Clinical study of the pathogenesis of intermenstrual bleeding

Objective To observe the pathogenesis of Intermenstrual bleeding.Methods Seventy patients suffering from intermenstrual bleeding were included as the study group and 35 subjects with normal menstruation were enrolled as the control group.The endometrial thickness,endocrine hormone levels and blood coagulation indicators in different phases of menstruation were measured.Results The endometrium of the intermenstrual bleeding group’s was significantly thicker than that of the control group 7～10 day at the menses but significantly thinner in 21～25 day of menses.There was significant statistical difference on FSH、LH、E2、P0 in 1～3 day.LH was significantly increased but decreased in 7～10 day,E2、P0 were decreased markedly in 21 ～25 day.No significant changes on blood coagulation indicators during the mense circle.Conclusion Low estrogen level before ovulation cannot support the thickening of the endometrium and subsequently causes bleeding,but it is not correlated with the coagulation mechanisms.