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| 喜树碱多相脂质体包封率测定方法及渗漏的研究 | |
| 引用本文： | 张清民,顾学裘,沙沂,张永恒. 喜树碱多相脂质体包封率测定方法及渗漏的研究[J]. 药学学报, 1987, 22(12): 918-922 |
| 作者姓名： | 张清民 顾学裘 沙沂 张永恒 |
| 作者单位： | 沈阳药学院(张清民，顾学裘，沙沂)，哈尔滨医科大学肿瘤医院药剂科(张永恒) |
| 摘 要： | 本文应用一阶导数分光光度法,不经分离喜树碱多相脂质体中包封的喜树碱与游离的喜树碱直接测定了喜树碱多相脂质体的包封率,结果为73.±3.4%。同时考查了影响喜树碱多相脂质体渗漏的因素。 |
| 关 键 词： | 多相脂质体 喜树碱 导数分光光度法 |
| 收稿时间： | 1986-11-20 |
A METHOD FOR DETERMINING THE ENCAPSULATION RATIO OF CAMPTOTHECIN IN POLYPHASE LIPOSOME AND STUDIES ON ITS LEAKAGE PROPERTY |
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| ZHANG Qing-Min,GU Xue-Qiu,SHA Yi and ZHANG Yong-Heng. A METHOD FOR DETERMINING THE ENCAPSULATION RATIO OF CAMPTOTHECIN IN POLYPHASE LIPOSOME AND STUDIES ON ITS LEAKAGE PROPERTY[J]. Acta pharmaceutica Sinica, 1987, 22(12): 918-922 | |
| Authors: | ZHANG Qing-Min GU Xue-Qiu SHA Yi ZHANG Yong-Heng |
| Abstract: | A new method, first order derivative spectrophotometry, for determining the encapsulation ratio of camptothecin in the polyphase liposome is introduced in this article. Compared with others, this method has many advantages such as simple, correct, fast, etc. The size and shape do not interfere with the accuracy of the result. The encapsulation ratio determined with this method is 73.0±3.4% (n=5). Using this method, we have studied the leaking property of camptothecin in the polyphase liposome. The results indicate that the leakage speed of camptotthecin from the polyphase liposome is easily influenced by temperature, pH, medium, and by the extent of oxidation of the membrane components. |
| Keywords: | Polyphase liposome Camptothecin Derivant spectrophotometry |
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