益肾胶囊联合贝那普利治疗慢性肾衰临床研究

目的观察益肾胶囊联合贝那普利治疗慢性肾衰（CRF）的疗效。方法选择CRF患者130例，随机分为中西医结合组66例和西药组64例，基于肾衰常规干预措施之上，中西医结合组予益肾胶囊＋贝那普利治疗，西药组单纯应用贝那普利治疗。疗程均为1年。以血清肌酐（Scr）、肌酐清除率（Ccr）、尿素氮（BUN）肾功三项为评定指标，Kaplan-meier过程评定肾生存情况。结果治疗后两组Scr均升高，以西药组升高幅度较大，组间比较差异有统计意义（P〈0．05）。1年肾脏生存率中西医结合组和西药组分别是60．6％和39．1％（X^2=5．475，df=1，P=0．019）。结论益肾胶囊联合贝那普利延缓CRF效果优于单纯西药治疗。

The research of Yishen Capsule combine with Benapril for chronic renal failure

Objective To observe the curative effect of Yishen Capsule combine with Benapril for chronic renal failure（CRF）. Methods 130 cases of CRF were divided into Chinese combined with Western medicine group （66 cases） and Western medicine group （64 cases）. On the base of normal therapy, the Chinese combined with Western medicine group were given Yishen Capsule and Benapril while the Western medicine group only given Benapil. The course of treatment was one year. Scr, Ccr, BUN were regarded as evaluated index, assessed the kidney existence in Kaplan-meier. Results Scr ascended in 2 groups after treated. But the Western medicine group was superior to the other group （ P 〈 0. 05）. The kidney existence rate in one year were 60.6 % and 39.1% respectively in Chinese combined with Western medicine group and Western medicine group （ X^2 =5. 475 ,dr= 1 ,P =0.019）. Conclusion Yishen Capsule combine with Benapril was superior to pure Western medicine in prolong CRF.