| 高同型半胱氨酸血症与心血管疾病 |
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| 引用本文： | 陈凤英,郭艳红,高炜.高同型半胱氨酸血症与心血管疾病[J].内蒙古医学院学报,2006,28(5):475-479. |
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| 作者姓名： | 陈凤英 郭艳红 高炜 |
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| 作者单位： | 1. 内蒙古医学院附属医院,急诊科,内蒙古,呼和浩特,010050
2. 北京大学第三医院,心内科 |
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| 摘 要： | 同型半胱氨酸是蛋氨酸代谢的中间代谢产物，先天或后天因素使代谢途径一些酶的缺乏／失活或辅助因子叶酸、维生素B6、维生素B12的缺乏导致高同型半胱氨酸血症。血中同型半胱氨酸升高引起血管损害．使内皮细胞受损、平滑肌细胞增殖／迁移、胶原分泌增多、促进血栓的形成，参与动脉粥样硬化、血管成形术后再狭窄，影响心脏的结构功能，是心血管疾病的独立危险因素。
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| 关 键 词： | 同型半胱氨酸 心血管疾病 危险因素 |
| 文章编号： | 1004-2113（2006）05-0475-05 |
| 收稿时间： | 2006-02-10 |
| 修稿时间： | 2006-08-05 |
HYPERHOMOCYSTEINEMIA AND CARDIOVASCULAR DISEASE |
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| CHEN Feng-ying,GUO Yan-hong,GAO Wei.HYPERHOMOCYSTEINEMIA AND CARDIOVASCULAR DISEASE[J].Acta Academiae Medicinae Neimongol,2006,28(5):475-479. |
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| Authors: | CHEN Feng-ying GUO Yan-hong GAO Wei |
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| Institution: | Department of Emergency Medicine and Critical Care, Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050 China |
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| Abstract: | Homocysteine is the middle product of metabolism, owing to congenital or postnatal factors, hyperhomocysteinemia can result from the deficiency or inactivation of some enzymes in related metabolic pathways or deficiency of accessory factors such as folacin, vitBr,vitB12. The rising of homocysteine in blood can lead to vascular lesion, impairing of endothelial cells, proliferation or migration of smooth muscle cells, increasing secretion of collagen, accelerating the form of thrombosis, participating with restenosis after angioplasty and atherosclerosis, affecting structure function of heart. Besides, it is viewed as a independent risk factor for cardiovascular diseases. |
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| Keywords: | homocysteinc cardiovascular disease risk factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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