微粒化非诺贝特对混合性高脂血症患者血清内皮素和一氧化氮含量的影响

目的　观察微粒化非诺贝特调脂作用及对血清内皮素 (ET - 1 )和一氧化氮 (NO)的影响。方法　 42例高脂血症患者给予微粒化非诺贝特 2 0 0mg ,每晚一次 ,8周为 1个疗程。试验前和用药后 8周取血检测相关指标。结果　治疗 8周后血清总胆固醇 (Tc)、三酰甘油 (TG)、低密度脂蛋白胆固醇(LDL -C)、ET - 1显著低于治疗前水平 (P <0 .0 1 ) ,高密度脂蛋白胆固醇 (HDL -C)和NO显著升高 (P<0 .0 1 ,P <0 .0 5 )。结论　微粒化非诺贝特有效降低血脂的同时起到内皮保护作用。

Effects of Micronised Fenofibrate on the Level of Serum Endothelin-1 and Nitric Oxide in Hyperlipidemic Patients

Objective To examine the effects of micronised fenofibrate on the levels of serum endothelin-1(ET-1)and nitric oxide(NO) in hyperlipidemic patients. Methods 42 patients with hyperlipidemia were treated with micronised fenofirate(200 mg a day,8 weeks).Blood lipid and the concentrations of ET-1 and NO were measured before and after 8 weeks treatment.Results The levels of TC,LDL-C and ET-1 decreased significantly while the levels of HDL and NO greatly increased after treatment(P<0.05).Conclusion Micronised fenofibrate may improve hyperlipidemic and the endothelial function by the inhibition of ET-1 secreation and the introducing of NO release.