不同剂量米非司酮治疗围绝经期功能失调性子宫出血临床观察

目的：分析不同剂量米非司酮治疗围绝经期功能失调性子宫出血的疗效和安全性。方法收集围绝经期功能失调性子宫出血的患者80例,根据米非司酮用量5 mg、10 mg及25 mg分别分为低剂量组26例、中剂量组26例及高剂量组28例,分别观察治疗3个月后的临床效果、子宫内膜厚度变化、性激素水平变化及不良反应发生情况。结果经治疗后,中剂量组（有效率92．3％）和高剂量组（有效率82．1％）的治疗效果优于低剂量组（有效率61．5％）,差异有统计学意义（F＝3．98,P＜0．05）;中剂量组及高剂量组抑制子宫内膜作用优于低剂量组（F＝4．34,P＜0．05）;三组都对性激素的体内水平有明显的降低作用;治疗过程中高剂量组的不良反应发生较多,高于低剂量及中剂量组（F＝3．97,P＜0．05）。结论米非司酮治疗围绝经期功能失调性子宫出血应用10 mg剂量效果较好,不良反应少,值得临床推广应用。

Clinical effect of different doses of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding

Objective To analyze the effect and safety of different doses of mifepristone treating perimenopa-usal dysfunctional uterine bleeding.Methods 80 patients with perimenopausal dysfunctional uterine bleeding were collected.According to the medicine of 5,10mg,25mg mg doses,80 cases were divided into the low dose group （n=26）,middle dose group （n=26） and high dose group （n=28）.The treatment results,endometrial thickness change, sex hormone level change and the adverse reaction were observed after 3 months.Results In terms of treatment effect,the effective rate in the middle dose group （92.3%） and high dose group （82.1%） were better than that of the low dose group（61.5%）（F=3.98,P〈0.05）;The inhibitory effect of endometrium in the middle dose group and high dose group were superior to the low dose group（ F=4.34,P〈0.05）;All three groups of sex hormone level was significantly lower in the body;Middle and high dose group of the adverse reactions of treatment process was more,the adverse reaction happening far higher than that of the low dose and dose group （F=3.97,P〈0.05）. Conclusion 10mg mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding has good effect, less adverse reactions,which is worthy of clinical application.