纳米碳对甲状腺手术中甲状旁腺的保护作用

目的：探讨纳米碳用于甲状腺手术中对甲状旁腺的保护作用。方法将72例患者随机分为两组各36例，对照组按甲状腺手术常规进行；观察组在甲状腺手术中，于甲状腺上下取2～5个点，在真被膜下方注入0．1～0．2 mL纳米碳混悬液，待甲状腺和周围淋巴组织染色后，完整游离甲状腺外科包膜，保护未染色组织，再常规行甲状腺手术。结果观察组术后发生低钙血症2例（5．6％），对照组6例（16．7％），两组差异有统计学意义（χ^2=13．87，P＜0．05）；观察组术后发生甲状旁腺功能减退1例（2．8％），对照组为5例（13.9％），两组差异有统计学意义（χ^2=14．53，P＜0．05）；观察组病理切片证实无误切甲状旁腺，对照组误切甲状旁腺7例（19．4％），两组差异有统计学意义（χ^2=127．54，P＜0．05）。结论在甲状腺手术中使用纳米碳，可帮助鉴别淋巴结及甲状旁腺，从而降低甲状旁腺的损伤率。

Protective effects of carbon nanoparticles on parathyroid gland during thyroidtomy

Objective To discuss the role of naso-carbon in the protection of parathyroid during surgery. Methods 72 patients were randomly divided into the two groups,Injecting 0.1-0.2mL nano-carbon in the thyroid during a thyroid surgery.When the thyroid and surrounding lymph tissue were stained,then the thyroid surgery should be continued,the non-stained tissue should be protected.Results There were 6 cases with hypocalcemia in the con-trol group and 2 cases in the observation group（χ^2=13.87,P〈0.05）.5 cases with PTH decrease in the control group and 1 case in the observation group（χ^2=14.53,P〈0.05）.7 parathyroid glands were examined in the control group,while none in the observation group（χ^2=127.54,P〈0.05）.Conclusion Using naso-carbon during the thy-roid surgery,parathyroid gland cannot be stained black.The parathyroid gland can be easily identified and preserved.