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| 苦丁茶提取物对D-半乳糖致衰老小鼠学习记忆的影响 | |
| 引用本文： | 周卫华,米长忠,吴仕筠,钟飞. 苦丁茶提取物对D-半乳糖致衰老小鼠学习记忆的影响[J]. 中国老年学杂志, 2011, 31(19) |
| 作者姓名： | 周卫华 米长忠 吴仕筠 钟飞 |
| 作者单位： | 吉首大学医学院,湖南 吉首,416000 |
| 摘 要： | 目的 观察苦丁茶提取物对D-乳糖致衰老模型小鼠学习记忆能力及抗氧化能力的影响.方法 40只小鼠随机分为正常组,模型组,低剂量组处理组( 10 g/kg),高剂量组处理组(20 g/kg),0.8% D-gal皮下注射6w建立衰老小鼠模型,同时灌胃给予不同剂量苦丁茶提取物.6 w后用Morris水迷宫实验检测小鼠的学习记忆能力,处死小鼠检测脑组织超氧化物歧化酶(SOD)活力以及丙二醛(MDA)含量.结果 与模型组相比,不同剂量处理组小鼠学习记忆成绩均明显提高(P＜0.05),脑组织SOD活力升高(P＜0.05),MDA含量下降(P＜0.05).结论 苦丁茶提取物可改善D-gal衰老模型小鼠的学习记忆能力,其机制可能与其具有抗氧化能力有关. |
| 关 键 词： | D-半乳糖 学习记忆 苦丁茶 |
Effect of Ilex Kudingcha extracts on learning and memory disturbance in aging mice by D-galactose |
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| ZHOU Wei-Hua,MI Chang-Zhong,WU Shi-Jun,et al.. Effect of Ilex Kudingcha extracts on learning and memory disturbance in aging mice by D-galactose[J]. Chinese Journal of Gerontology, 2011, 31(19) | |
| Authors: | ZHOU Wei-Hua MI Chang-Zhong WU Shi-Jun et al. |
| Affiliation: | ZHOU Wei-Hua,MI Chang-Zhong,WU Shi-Jun,et al. Jishou University School of Medicine,Jishou 416000,Hunan,China |
| Abstract: | Objective To observe effects of Ilex Kudingcha extracts on learning and memory function and antioxidative ability of aging model mice induced by D-galactose.Methods 40 mice were randomly divided into control,model,low dose treated(10 g/kg),high dose treated groups(20 g/kg).Senile model mice were established by D-galactose hypodermic injection for 6 weeks.The different doses of Ilex Kudingcha extracts had been administered to two therapy groups.After 6 weeks all the mice of different groups were tested with ... |
| Keywords: | D-galactose Learning and memory Ilex kudingcha CJ Tseng |
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