核素骨显像联合肿瘤标记物检测对乳腺癌骨转移的诊断价值

目的：观察核素骨显像联合肿瘤标记物对乳腺癌骨转移的诊断价值。方法选择乳腺癌患者82例，按照核素骨显像结果分为转移组43例及未转移组39例，另选取40例健康体检女性作为对照组。观察核素骨显像以及肿瘤标记物检测结果，并对其诊断价值进行考察。结果转移组血清CA125、CA15-3及CEA表达水平及阳性率显著高于未转移组及对照组，骨转移灶数目≤2患者血清CA125、CA15-3以及CEA表达水平及阳性率均显著低于骨转移灶数目＞2的患者，差异均具有统计学意义（P＜0．05）。且随着骨转移分级程度的升高，患者乳腺癌相关肿瘤标记物CA125、CA15-3及CEA表达水平及阳性率均呈升高趋势，各分级间差异有统计学意义（ P＜0．05）。结论核素骨显像联合肿瘤标记物检测可提高诊断敏感性，对于乳腺癌骨转移的诊断具有重要的参考价值。

Application of Radionuclide Bone Imaging Combined with Tumor Markers in the Diagnosis of Bone Metastasis in Breast Cancer Patients

Objective To observe the application value of radionuclide bone imaging combined with tumor markers in the diagnosis of bone metastasis in breast cancer patients .Methods 82 breast cancer patients were divided into metastasis group with 43 cases and premetastasis group with 39 cases according to the result of radionuclide bone imaging .Then 40 healthy women were selected as the control group .The results of radionuclide bone imaging and tumor markers were observed ,and the diagnostic value were compared.Results The expression level and positive rate of serum CA 125,CA15-3 and CEA of metastasis group were obviously higher,there had statistically difference (P<0.05).The expression level and positive rate of serum CA125,CA15-3 and CEA in patients with number of bone metastasis ≤2 of metastasis group was lower than patients with number of bone metasta-sis >2,there had statistically difference (P<0.05).The serum levels of CA125,CA15-3 and CEA increased gradually as bone metastatic grading increased (P<0.05).Conclusion Radionuclide bone imaging combined with tumor markers can improve the diagnostic sensitivity ,which is an important reference in the diagnosis of bone metastasis in breast cancer patients .