改良DT-Vel与标准DT-Vel方案治疗多发性骨髓瘤的疗效比较

目的:评估两种硼替佐米方案治疗多发性骨髓瘤（MM）的疗效及安全性。方法:34例MM患者采用改良及标准DT-Vel方法。结果:16例改良DT-Vel方案的患者，4例CR，5例PR，3例VGPR，2例MR，2例未评价，ORR为75.0%。相较18例标准DT-Vel方案患者4例CR，6例PR，4例VGPR，4 例MR，ORR为77.8%，无统计学差异。结论:改良DT-Vel方案与标准DT-Vel方案疗效相当，患者耐受性好，是一种值得推荐的治疗MM安全、有效的方法。

Comparison of efficacy and safety between modified DT -Vel and standard DT -Vel regi-men in the treatment of multiple myeloma

Objective:To evaluate the curative effect of Bortezomib in treatment of newly diagnosed multiple mye-loma.Methods:Thirty -four patients with newly diagnosed multiple myeloma received improved and the standard DT-Vel chemotherapy regimen.Results:In improved DT -Vel,4 patients complete remission,5 patients were partial remission,3 patients very good partial remission,2 mild remission,2 patients were not evaluated.overall response rate was 75.0%.In standard DT -Vel 4 complete remission,6 partial remission,4 very good partial remission,4 mild re-mission,overall response rate was 77.8%.Conclusion:Improved DT -Vel is well tolerated and effective in treatment of newly diagnosed multiple myeloma.