补阳还五汤对动脉粥样硬化大鼠模型血脂的影响

目的利用高脂饲料加维生素D3诱发的动脉粥样硬化（AS）模型，观察益气活血代表方剂补阳还五汤对AS模型血脂的影响，探讨其治疗作用及可能机制。方法大鼠动脉粥样硬化造模成功后，随机分为4组。补阳还五汤治疗组：造模成功后给予补阳还五汤17．5g／（kg·d）灌胃；川芎嗪治疗组：造模成功后给予川芎嗪0．2g／（kg·d）灌胃；正常对照组一直饲喂普通饲料；模型组造模成功后改喂普通饲料。灌胃30d。用药一月后测定血脂水平。结果高脂饮食加维生素D3可诱导大鼠形成动脉粥样硬化模型，模型组的血脂明显高于正常组。补阳还五汤治疗组的总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL）水平均显著低于川芎嗪治疗组、模型组。结论益气活血的代表方剂补阳还五汤具有抗动脉粥样硬化作用，下调血脂水平可能是其作用机制之一。

Effect of Buyang Huanwu Decoction on Blood Lipid in Atherosclerosis Rats

Objective To study the effect of Buyang Huanwu decoction（BHD） on blood -lipid in atherosclerosis（AS） rat models. Methods After the AS rat models establishment, the rats were divided into 4 groups at random （8 rats per group）：BHD therapy group, ligustrazine therapy group, normal control group, and model group. After treatment for 1 month, the levels of blood- lipid were detected. Results High fat diet and vitamin D3 could induce atherosclerosis in rat. Comparing with normal control group,the level of tota! cholesterol （TC）,triglyceride （TG） and low- density lipoprotein （LDL） in model group was increased. Comparing with ligus- trazine therapy group and model group, the levels of TC, TG, and I.DI. in BHD therapy group were decreased significantly. Conclusion BHD had anti - atherosclerotic effects by down - regulating the levels of blood lipid.