地特胰岛素联合餐前速效胰岛素与胰岛素泵对2型糖尿病的疗效比较

【目的】比较地特胰岛素联合餐前速效胰岛素及胰岛素泵对2型糖尿病患者（T2DM）疗效。【方法】选取78名T2DM患者，随机分为地特胰岛素联合餐前速效胰岛素组（Ⅰ组）及胰岛素泵组（Ⅱ组），比较两组疗效、安全性、治疗费用及生活质量等指标。【结果】两组患者治疗后血糖水平均较治疗前有显著改善（P〈0．05），达到预期指标。Ⅱ组患者生活质量较治疗前及Ⅰ组显著提高（P〈0．05）；两组患者均未发生低血糖事件及过敏反应，Ⅱ组血糖达标时间及胰岛素用量较Ⅰ组显著降低（P〈0．05），但费用增加（P〈0．05）。【结论】两种治疗方式各具特色，临床上应该根据患者自身情况，灵活实际地选择用药方式，以达到最佳的治疗效果。

Comparison of the Efficacy of Insulin Detemir Combined with Pre-meai Short-action Insulin vsContinuous Insulin Pump for the Treatment of Type 2 Diabetes Mellitus

[Objective] To compare the efficacy of insulin detemir combined with pre-meal short-action in- sulin vs continuous insulin pump for the treatment of patients with type 2 diabetes mellitus（T2DM）. [Meth- ods] A total of 78 T2DM patients were selected and randomly divided into insulin detemir combined with pre- meal short-action insulin group（group I ） and continuous insulin pump group（group 11 ）. The efficacy, safe- ty, treatment cost and quality of life were compared between two groups. [Results] Compared with before treatment, blood glucose in two groups after treatment was improved significantly（ P 〈0.05）, and reached the expected level. Compared with before treatment and group Ⅰ, the quality of life in group Ⅱ was significant- ly improved（ P 〈0.05）. No hypoglycemia and allergic response occurred in patients of two groups. Compared with group Ⅰ , the time for glycemia up to the standard and insulin dosage in group Ⅱ significantly decreased （ P〈0.05）, but the cost increased（ P 〈0.05）. [Conclusion]Two treatment ways have their own characteris- tics. In clinical practice, the treatment way should be actively and actually chosen on the basis of the situation of the patients in order to obtain the best clinical efficacy.