Behavioral assessment of functional deficit in rats with contusive spinal cord injury |
| |
| Authors: | H Kerasidis J R Wrathall K Gale |
| |
| Affiliation: | 1. Department of Anatomy Georgetown University, Schools of Medicine and Dentistry, Washington, DC 20007 U.S.A.;2. Department of Pharmacology, Georgetown University, Schools of Medicine and Dentistry, Washington, DC 20007 U.S.A.;1. Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA;2. Division of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, MO, USA;1. Resident, Department of Oral and Maxillofacial Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland;2. Professor, Department of Oral and Maxillofacial Surgery, University of Turku, and Turku University Hospital, Finland;3. Consultant, Department of Oral and Maxillofacial Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland;4. Professor, Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, and University of Eastern Finland, Institute of Dentistry, Kuopio, Finland;6. Consultant, Department of Oral and Maxillofacial Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland;1. Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Florida College of Medicine, Gainesville;2. Department of Surgery, Division of Plastic and Reconstructive Surgery, Miami, FL;3. Department of Neurological Surgery, The Neuroscience Program, The Interdisciplinary Stem Cell Institute, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL;1. Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan;2. Medical Affairs Department, Pharmaceutical Business Administration Division, Asahi Kasei Pharma Corporation, Japan;3. Professor Emeritus, Osaka University, Japan;1. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;2. Department of Neurosurgery, Jinling Hospital, Nanjing 210000, China;1. Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA;3. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA;4. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA;5. Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA;2. International Clinical Research Center, St. Anne''s University Hospital Brno, Brno, Czech Republic |
| |
| Abstract: | ![]()
We have previously reported a method for assessing functional deficits in rats after contusive spinal cord injury in which a Combined Behavioral Score (CBS) is calculated that is indicative of the overall percent deficit (Exp. Neurol., 88: 123-134, 1985). The test battery used includes several neurologic tests as well as the Motor Score in which use of the hindlimbs in locomotion is graded. In this report we present correction criteria in order to reduce potential interlaboratory variability in assessing functional deficit by the CBS. Groups of rats were subjected to contusive injury using a weight drop technique. The calculated CBS at 4 weeks was compared to that obtained if the Motor Score was over- or underestimated by 1 grade. The results indicated a considerable effect on the calculated CBS, especially when the Motor Score was underestimated in mildly injured animals. Behavioral test data were examined in terms of the distribution of the responses to the various other behavioral tests in relation to the Motor Score. The results were used to develop a set of correction criteria that minimized the effects on the CBS of subjective errors in the Motor Score. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
