快速肠道准备方法联合益生菌制剂用于术前肠道准备的效果观察

目的 观察快速肠道准备方法联合益生菌用于术前肠道准备的效果.方法 124例择期行手术治疗结直肠癌患者按照肠道准备方式不同随机分为益生菌组(65例)和对照组(59例),对照组于术前采用传统的3d肠道准备方法;益生菌组于术前采用1d快速肠道准备方法,并给予益生菌制剂口服.观察两组患者的体温、心率变化及术后第1、8天检测全血细菌DNA比值,观察外周血白细胞计数及全身炎症反应综合征(SIRS)和并发症发生情况.结果 益生菌组术后发热时间(4.15±0.89)d、心率(89.91±8.59)次/min,明显低于对照组的(6.34±1.12)d、(104.27±11.67)次/min(t=11.52、20.07,均P＜0.05);益生菌组白细胞计数恢复正常时间(4.59±0.29)d、全血细菌DNA阳性率3.30％( 2/65),与对照组的(7.24±0.24)d、26.67％( 8/59)差异均有统计学意义(t=5.07,x2=34.68,均P＜0.05);益生菌组SIRS发生率72.31％ (47/65),与对照组的76.27％ (45/59)差异无统计学意义(P＞0.05);两组切口感染发生率分别为4.35％ (3/65)、3.39％(2/59),腹腔感染发生率分别为1.45％( 1/65)、1.69％ (1/59),两组差异均无统计学意义(均P＞0.05).结论 快速肠道准备方法联合益生菌制剂能提高肠道准备效果,有利于患者术后早期炎性反应的恢复.

Efect of rapid intestinal preparation combined with probiotics in bowel preparation before operation

Objective To explore the effect of rapid intestinal preparation combined with probiotics in bowel preparation before operation. Methods 124 colorectal cancer patients were divided into the probiotic group （65 cases） and control group （59 cases）. Control group using traditional 3d bowel preparation, joint probiotic group, to give patients in the 1 d intestinal ready on the basis of probiotic oral. The two groups after patients received isonitrogenous and caloric nutritional support, were observed afttr the two groups of patients with body temperature and heart rate changes ; detection of bacterial DNA ratio of whole blood. Observed in peripheral blood leukocyte count, and systemic inflammatory response syndrome（SIRS） and the occurrence of complications. Results Probiotic group and control group, postoperative fever duration and postoperative heart rate and leukocyte counts return to normal a short time （t = 11.52,20.07, P 〈 0.05 ） ; whole blood PCR detection of bacterial DNA after the positive test group 2 cases （3.30%） , the control group was 8 cases （26. 67 % ）, the difference was statistically significant （ t = 5.07, x2 = 34.68, P 〈 0.05 ）. Postoperative SIRS rate and the incidence of complications showed no statistical difference （P 〉 0. 05 ）. Conclusion Probiotics could reduce colorectal cancer patients with postoperative intestinal permeability and reduce the incidence of bacterial translocation and its rapid intestinal preparation method was feasible and effective and knot the protection of the intestinal mucosal barrier function in rectal cancerconductive to knot the early postoperative in- flammatory response in patients with rectal cancer recovery.