| 番茄红素对D-半乳糖诱导衰老大鼠椎间盘的影响 |
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| 引用本文： | 兰观华,邵增务,刘之川,丁凡. 番茄红素对D-半乳糖诱导衰老大鼠椎间盘的影响[J]. 国际骨科学杂志, 2009, 30(1) |
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| 作者姓名： | 兰观华 邵增务 刘之川 丁凡 |
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| 作者单位： | 430022武汉,华中科技大学同济医学院附属协和医院骨科;430022武汉,华中科技大学同济医学院附属协和医院骨科;430022武汉,华中科技大学同济医学院附属协和医院骨科;430022武汉,华中科技大学同济医学院附属协和医院骨科 |
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| 摘 要： | 目的 观察D-半乳糖诱导衰老大鼠模型椎间盘等的变化及番茄红素对其影响.方法 将30只SD大鼠随机分成对照组、模型组和干预组.模型组和干预组每天颈部皮下注射D-半乳糖,对照组用等量生理盐水替代,干预组每天用番茄红素灌胃.各组每周称体重,12周后处死并取椎间盘及血清观测.结果 与对照组相比,模型组椎间盘明显退变,干预组椎间盘轻微退变;模型组体重减轻(P<0.05)、抗氧化水平下降明显(P<0.05.P<0.01).而干预组较模型组体重及抗氧化水平有所升高(P<0.05·P<0.01).结论 D-半乳糖在诱导大鼠衰老的过程中可诱发椎间盘退变.而番茄红素可延缓椎间盘退变的进展.
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| 关 键 词： | 番茄红索 D-半乳糖 衰老 椎间盘退变 |
The influence of lycopene on the intervertebral discs in D-galactose-induced rats |
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| LAN Guan-hua SHAO Zeng-wu LIU Zhi-chuan,et al.. The influence of lycopene on the intervertebral discs in D-galactose-induced rats[J]. International Journal of Orthopaedics, 2009, 30(1) |
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| Authors: | LAN Guan-hua SHAO Zeng-wu LIU Zhi-chuan et al. |
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| Affiliation: | LAN Guan-hua SHAO Zeng-wu LIU Zhi-chuan,et al. Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430022,China |
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| Abstract: | Objective To study the changes of intervertebral discs in D-galactose-induced rat aging model and the influence of lycopene on them.Methods Thirty SD rats were randomly divided into three groups,they were young control group,model group and lycopene group.Rats in model group and lycopene group were subcutaneously injected with D-galactose every day.rats in young control group were injected with equal volume of saline solution rats in lycopene group were orally administered with the lyeopene.All rats were we... |
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| Keywords: | Lycopene D-galactose Aging Intervertebral disc degeneration |
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