过敏性皮炎患者外周血IL-13、IL-4和嗜酸性粒细胞数检测

目的：探讨外周血中嗜酸性粒细胞（peripheralbloodeosinophilcell，PBEC）计数、人白介素13（interleukin-13．IL-13）和人白介素-4（interleukin-4，IL-4）水平的表达在过敏性皮炎发生发展中的作用．、方法：收集28例过敏性皮炎患者和40例健康查体者外周血标本，常规计数PBEC，并通过半定量酶联免疫吸附试验（ELISA）检测上述标本中的IL-13和IL-4的水平，采用t检验比较其间的差异。结果：过敏性皮炎患者外周血PBEC计数、IL-13和IL-4的水平显著高于健康对照组（P〈0．01），且过敏性皮炎组IL-13和IL-4水平呈显著正相关性（P〈0．05），结论：PBEC、IL-13和IL-4参与过敏性皮炎患者体内的变态反应，IL-13可能通过IL-4来发挥作用。

The detection of peripheral blood IL-13,IL-4 and eosinophil cells count in atopic dermatitis patients

Objective ： To investigate the correlation of PBEC, IL-4, IL-13 and atopic dermatitis. Methods ： The counting of peripheral blood eosinophil cells （PBEC） was performed by the routine method, and the level of serum IL-4 and IL-13 in 28 atopic dermatitis patients and 40 health adults was measured by ELISA.Results ： The amount of PBEC ,the level of serum IL-4 aii（t IL-13 in atopic dermatitis group was significantly higher than that in the health control （P〈0.01） , and there was a positive correlatioll between IL-4 and IL-13 in atopic dermatitis group（P〈0.05）. Conclusions ： There is an important role ofPBEC, IL-4 and IL-13 m atopic dermatitis, and IL-13 IL - 13 May play a role by IL - 4.