金属有机骨架材料在中药研究的应用进展

金属有机骨架材料(metal organic frameworks,MOFs)是由金属离子中心与有机配体连接而成的杂化多孔晶体材料,具有比表面积大、孔径可调、活性位点丰富、生物相容性良好的优点,被广泛用于气体储存、吸附、提取、催化及药物递送等领域。近年来,MOFs在中药研究领域的应用也越来越广泛,主要用于中药有效成分的缓控释放、靶向递送、改善药物的溶解性、增加药物的稳定性、降低药物的毒副作用等。此外,MOFs在中药成分的提取分离及检测方面也有诸多应用。综述近年来MOFs在中药研究领域的应用进展,以期为MOFs在中药研究中的进一步应用提供参考,为中药成分的新型递药系统研究提供新思路。

Progress in application of metal organic frameworks in traditional Chinese medicine

Metal organic frameworks (MOFs) are hybrid porous crystalline materials formed by connecting metal ion centers and organic ligands. They have the advantages of large specific surface area, adjustable pore size, abundant active sites, and good biocompatibility. They are widely used in the fields of gas storage, adsorption, extraction, catalysis, and drug delivery. In recent years, MOFs have become more and more extensive in the field of traditional Chinese medicine research, mainly used for slow and controlled release of active ingredients of traditional Chinese medicine, targeted drug delivery system, improvement of drug solubility, increase of drug stability, and reduction of drug side effects, etc. At the same time, MOFs also have many applications in the extraction, separation and detection of Chinese medicine components. The application progress of MOFs in the field of traditional Chinese medicine research in recent years is reviewed in this paper, hoping to provide a reference for the further application of MOFs in the research of traditional Chinese medicine, and provide new ideas for the research of new drug delivery systems based on traditional Chinese medicine components.